Description
The telomerase is an enzyme that is essential for cell replication and maintaining the integrity of chromosomes. It is responsible for the production and maintenance of telomeres, which are protective ends of chromosomes. Over time, telomeres naturally shorten with each cell division cycle, which can eventually lead to cell death or the development of age-related diseases.
It has multiple recognized actions:
- Anti-aging action by limiting the effects of cellular senescence and preserving genetic heritage.
- Cardio-protective and arterio-protective action.
- Cellular protection against oxidative stress.
- Reinforcement of immunity.
- Energizing and anti-fatigue action.
- Healing action.
Each chromosome is protected at both ends by telomeres, which are repetitive non-coding nucleic acids. Telomeres have no genetic information function but serve the purpose of protection. During cell division, cells lose a portion of their protective telomeres. After a certain number of divisions, the telomeres, which are only partially repaired each time, will disappear, leaving the chromosome unprotected. In the next division, the informational genetic code of the cell will be altered, leading to cell death in the best case scenario, or the transformation of the cell into a cancerous cell in other cases.
Maintaining telomere length is crucial for cellular health, and the only way to achieve this is by stimulating telomerase, the enzyme responsible for repairing and lengthening telomeres.
Why choose our product to support your health?
Our products are manufactured in the heart of France, in the Loire Valley.
Through our partner laboratories, all our products are certified organic.
Our product is exclusively composed of natural ingredients and is guaranteed free of additives and GMOs.
The formulation of our products has been studied with the highest expertise to ensure optimal physiological correction for your well-being.
By following the indicated dosage, our physiological corrector will cost you €121.33 per month.
Invest in your health with Longevity Sciences Lab.
CRITICAL ANALYSIS OF SCIENTIFIC LITERATURE ON TELOMERASE
Telomerase, an antiaging enzyme
During aging, gradual loss of telomeric DNA in the cell nucleus during DNA replication leads to senescence. Hence, accelerated shortening reveals many aging diseases and early death. A study tried to evaluate the connection between telomere length and mortality in 143 individuals aged more than 60. Those who had the shortest telomeres in the blood DNA had a lower chance of survival, which can be in part because of the cardiac mortality rate that is 3.18 times higher and the mortality rate that is 8.54 times higher in the case of infectious diseases. These results support the hypothesis according to which telomere shortening in the human person contributes to numerous aging diseases (1).
Zinc, an efficient agent for telomere quality
Our dietary supplement TELOMERASE PLUS contains zinc. It is an essential trace element for the functioning of the immune system because the zinc ions are involved in the activity of immune cells. Zinc has also demonstrated its anti-inflammatory and antioxidant properties (2). A study concluded that zinc, as an antioxidant could improve age-related characteristics. Indeed, telomere extension, increased expression of the telomere gene, and a greater telomerase activity are elements limiting senescence (3).
Astragalus, a plant of longevity
Astragalus is a major medicinal herb of Chinese traditional medicine that is commonly used in multiple formulations to treat a wide variety of diseases and body disorders. It has been sold in the form of extracts that extend human life in China for more than 2000 years. Pharmaceutical research indicates that astragalus extract component can improve telomerase activity and has antioxidant effects that neutralize free radicals that disturb cell functioning. It is also associated with anti-inflammatory and anticancer properties. Moreover, the extract is interesting because it is a lipid-lowering, hyperglycemic, and also hepatoprotective agent. Finally, astragalus extract has expectorant and diuretic properties. An astragalus dry-root extract, called TA-65, has been associated with a significant anti-aging effect on the immune system (4). Indeed, a recent 2021 study argues that cycloastragenol, a molecule present in astragalus, is currently the only natural telomerase activator (5).
Astragalus extract has proven its effects on humans
A study was led on 117 patients positive to cytomegalovirus, a virus of the herpes family. These patients were between 53 and 87 years old, and half of them received the astragalus extract, TA-65, which activates telomerase, and the other half received a placebo. This study summarizes the results on the length change of telomeres over a one-year period. It was shown that the patients taking the TA-65 intake significantly increased the length of their telomeres during the 12-month period, whereas those receiving the placebo significantly saw a reduction in telomere size. Therefore, the results suggest that TA-65 can statistically and clinically extend telomeres in a significant manner (6).
Demonstrated efficiency of Telomerase Plus on artery rigidity
It has been demonstrated by Doctor Christophe de JAEGER’s team that a molecular complex like TELOMERASE PLUS can extend telomeres and allow an improvement of artery rigidity (7).
Demonstrated efficiency of astragalus extracts: cycloastragenol and astragaloside IV
It has recently been demonstrated that two small molecule telomerase activators, derived from astragalus, called astragaloside IV and cycloastragenol improve the lymphocyte T CD8 + proliferative response of people infected with HIV by regulating the activity surge of telomerase. T CD8 lymphocytes are cells that protect us from pathogens. They are part of our immune system (8).
Astragaloside IV, an astragalus extract has an effect against diabetic syndromes
Diabetic nephropathy is a complication that affects the kidney and that is a common symptom of diabetes. Astragaloside IV, an astragalus extract offers various pharmacological properties, especially a protective effect in diabetic people. In vivo and in vitro experiments have confirmed that astragaloside IV has oxidative anti-stress effects, hence against the harmful effects of free radicals on cells, but also anti-inflammatory ones. Astragaloside IV also plays an anti-epithelial-mesenchymal role. That means that it prevents the phenomenon by which kidney cells are forcefully transformed into fibrosis. Fibrosis contributes to kidney necrotizing because of the thickness of its tissue. Thanks to these properties, astragaloside IV improves renal lesions caused by high glycemia (9).
The cardio protective effect of astragalus extract
Cardiovascular diseases are the first cause of deaths in the world. Chinese traditional medicine has long proven to have a significant impact on the treatment of cardiovascular diseases. Astragalus is a traditional Chinese medicinal plant that is commonly used. Studies have shown that astragalus has anti-tumor properties, can regulate the metabolism, and reinforce immunity and the heart. Astragaloside IV is an active ingredient in astragalus, which plays a primordial role in cardiovascular diseases. It can protect against ischemic and hypoxic lesions, meaning artery narrowing. It can inhibit myocardial hypertrophy and myocardial fibrosis, hence the thickening and the narrowing of ventricular walls. It can improve myocardial contractility and diastolic disorders, meaning improving muscular function, attenuating vascular endothelial disorders, and fostering angiogenesis. This last phenomenon is associated with the creation of new vessels. Moreover, astragalus extract will also regulate glycemia and blood lipid levels and thus reduce the risk of cardiovascular diseases (10).
Telomerase has an effect on metabolic syndrome
The telomerase activator, a compound extracted from astragalus called cycloastragenol, is used in Chinese traditional medicine to extend life expectancy. A study led on 40 metabolic syndrome patients was made to evaluate the effects of the cycloastragenol molecule also called TA-65, on this at-risk population. Metabolic syndrome designates a set of consequences due to excessive weight fat. This study was led over the course of 12 weeks, during which half of the patients had to take 16 mg of a TA-65 supplement, and the others a placebo. The results were that those who had taken the TA-65 intake displayed higher HDL cholesterol, which is the “good cholesterol” that carries excessive cholesterol in the blood to the liver, where it will be destroyed. The study associates this positive change to an inflammation reduction. Furthermore, the body mass index, the waist size and the LDL/HDL ratio were reduced for those having taken TA-65 compared to those that took the placebo. Finally, there were fewer factors leading to tumor necrosis in those that received the TA-65 intake. The factors prompting tumor necrosis are proteins involved in the inflammation (11).
- R M Cawthon, K R Smith, E O’Brien, Association between telomere length in blood and mortality in people aged 60 years or older, Lancet, February 2003
- R Farahzadi, E Fathi, S Alirez Zinc sulfate contributes to promote telomere length extension via increasing telomerase gene expression, telomerase activity and change in the TERT gene promoter CpG island methylation status of human adipose-derived mesenchymal stem cells, Public Library of Science one, November 2017
- P Liu, H Zhao, Y Luo, Anti-Aging Implications of Astragalus Membranaceus (Huangqi): A Well-Known Chinese Tonic, Aging and disease, December 2017
- S Duman, G Ekiz, S Ylmaz, Telomerase activators from 20(27)-octanor-cycloastragenol via biotransformation by the fungal endophytes, Bio-organic Chemistry, April 2021
- L Salvador, G Singaravelu, Calvin B Harley, A Natural Product Telomerase Activator Lengthens Telomeres in Humans: A Randomized, Double Blind, and Placebo Controlled Study, Rejuvenation research, December 2016
- de Jaeger C, Lamberti C, Van Leeuwen V, Voronska E, Kruiskamp S (2021) Results of a preliminary study on the effects of a compound on telomeres length, biological and physiological parameters. J Biol Med 5(1): 008-015. DOI: https://dx.doi.org/10.17352/jbm.000025
- L Y Yung, W S Lam, M KC Ho, Astragaloside IV and cycloastragenol stimulate the phosphorylation of extracellular signal-regulated protein kinase in multiple cell types, Planta medica, January 2012
- E Wang, L Wang, R Ding, Astragaloside IV acts through multi-scale mechanisms to effectively reduce diabetic nephropathy, Pharmacological Research, July 2020
- Y Q Tan, H W Chen, J Li, Astragaloside IV: An Effective Drug for the Treatment of Cardiovascular Diseases, Drug design, development and therapy, September 2020
- M L Fernandez, M S Thomas, Bruno S Lemos, TA-65, A Telomerase Activator improves Cardiovascular Markers in Patients with Metabolic Syndrome, Current Pharmaceutical Design, 2018
