Description
Oxidative stress is one of the major mechanisms of aging. As individuals age, oxidative stress increases, contributing to the acceleration of a vicious cycle. It is therefore important to help reduce this stress in the body. SOD is one of the key molecules against oxidative stress.
SOD fights against free radicals and prevents oxidative damage that contributes to senescence. By neutralizing free radicals, it helps protect cells and tissues in the body against the harmful effects of oxidation, thus combating aging.
Here are the properties described in the scientific literature:
- Protection against senescence
- Reduction of inflammation
- Support for cardiovascular health
- Protection against neurodegenerative diseases
- Improvement of skin health
- Enhancement of post-exercise recovery
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CRITICAL ANALYSIS OF SCIENTIFIC LITERATURE ABOUT SOD
- SOD against neurodegenerative diseases
SOD helps protect against neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease by reducing free radical levels in the brain.
A study was designed to correlate Alzheimer’s disease with the decrease in SOD in various regions of the brains of Alzheimer’s patients. It was found that the number of SOD-positive neurons in the temporal and frontal cortex and hippocampus of Alzheimer’s patients was significantly decreased. This indicates that Alzheimer’s disease may be linked to the decline of SOD, leading to neuropathological changes in this disorder. In fact, reactive oxygen species (ROS), which are free radicals, play an important role in physiological functions. The overproduction of these molecules, as well as the failure to neutralize them by the body’s antioxidant enzyme systems, leads to the destruction of cellular structures, lipids, proteins, and genetic material such as DNA and RNA. This oxidative stress has been considered to be related to the etiology of many diseases, including neurodegenerative diseases such as Alzheimer’s disease, Friedreich’s ataxia, Huntington’s disease, multiple sclerosis, and Parkinson’s disease. Similarly, a study demonstrated that SOD is an enzymatic antioxidant and its supplementation has been effective in preventing cognitive decline in cells.
- SOD supports cardiovascular health
SOD helps protect the cardiac system against oxidative damage in blood vessels, reducing the risk of cardiovascular diseases.
Free radicals can cause tissue damage of various kinds, including in the cardiac system. Cardiovascular lesions are responsible for mortality and morbidity worldwide. A study highlighted SOD in human therapy against ischemia (insufficient blood flow to an organ that can lead to irreversible damage). This study suggested that myocardial lesions due to ischemia would be improved by blocking free radical-mediated lesions. SOD, due to its antioxidant properties, has been proposed as a protective agent against free radicals in various experimental models.
- SOD against inflammatory diseases like arthritis
SOD helps reduce inflammation, which is a key factor in many chronic diseases such as arthritis, diabetes, and cardiovascular diseases.
A study showed that SOD is significantly decreased in human arthritic cartilage. Arthritis is a chronic condition characterized by joint pain, and its cause is cartilage wear. In this study, it was found that SOD activity in arthritic synovium of the knee was significantly lower than that in control synovium. The
synovium is the tissue that lines the inside of joints. These results indicate that regulating SOD activity in joint tissues can suppress the progression of arthritis.
- SOD against sun-induced skin aging
SOD helps protect the skin against damage caused by the sun and reduces age spots through its antioxidant action.
Indeed, a study was conducted in France by dermatologists on patients with high sensitivity to ultraviolet (UV) rays, a significant source of free radicals. UV rays cause premature skin aging, which is further exacerbated in individuals with fragile skin. The results showed a significant reduction in sunburns, as well as various allergic reactions resulting in skin rashes such as eczema or itching. SOD, through its anti-radical action, protected the fragile skin of these patients. Thus, superoxide dismutase is an effective anti-aging agent against the harmful effects of UV rays from the sun.
For more information, please consult our articles on the subject here.
References:
1. K Cao, YT Dong, J Xiang. Reduced expression of SIRT1 and SOD-1 and the correlation between these levels in various regions of the brains of patients with Alzheimer’s disease. Journal of Clinical Pathology, December 2018.
2. Md Torequl Islam. Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders. Neurological Research, January 2017.
3. V Balendra, SK Singh. Therapeutic potential of astaxanthin and superoxide dismutase in Alzheimer’s disease. Open Biology, June 2021.
4. R Ferrari, C Ceconi, S Curello. Superoxide dismutase: possible therapeutic use in cardiovascular disease. Pharmacological Research, 1989.
5. C Verdet. Clinical Research Regarding GliSODin® and Sun Exposure/UVB. International Journal of Integrated Health Science, June 2003.
6. M Koike, H Nojiri, H Kanazawa. Superoxide dismutase activity is significantly lower in end-stage osteoarthritic cartilage than non-osteoarthritic cartilage. PLOS ONE, September 2018.
